Ohio Faces Rising Threat from Carfentanil and New Synthetic Opioid

The state of Ohio is experiencing a troubling resurgence of carfentanil, a powerful synthetic opioid, alongside the emergence of a new opioid compound known as N-propionitrile chlorphine, or cychlorphine. The Ohio Bureau of Criminal Investigation (BCI) reported that there have been 199 instances of carfentanil identified in drug samples this year, marking a significant increase from previous years. Ohio Attorney General Dave Yost emphasized the dangers of these substances, stating, “The amateur chemists who create these deadly drug combinations don’t care if you live or die.”

Following a peak in 2017, when carfentanil was found in 1,119 drug samples, the state had seen a decline in occurrences. Nonetheless, the current rise in seizures poses a serious concern, affecting 46 counties across Ohio. The highest concentrations of carfentanil have been reported in central and northwestern regions, with a notable increase spreading into southern counties as well. Carfentanil has been detected in various forms, including powders, tablets, and liquids, exhibiting a range of colors from white to purple.

Emergence of Cychlorphine

In addition to carfentanil, BCI labs have identified cychlorphine, a new opioid compound that debuted in a tan powder form. This substance was linked to a non-fatal overdose incident in Fairfield, Butler County, where multiple doses of Narcan were required to revive the individual involved. The drug exhibits effects similar to those of fentanyl, raising alarms among health officials.

According to reports from the Drug Enforcement Administration (DEA), related incidents involving cychlorphine have also been documented in other states, including Tennessee in July 2025 and a prior seizure in Florida in April 2024. These developments highlight the ongoing challenges posed by the evolving landscape of synthetic opioids.

Yost’s office continues to warn the public about the lethal risks associated with unprescribed drug use. “If you take drugs that weren’t prescribed by your doctor, you risk lethal exposure to synthetic opioids,” he cautioned. As the situation develops, authorities are increasing their efforts to combat the spread of these dangerous substances and protect the health of Ohio residents.